Brother Lin is a railroad worker and is 50 years old. Brother Lin has a history of chronic hepatitis B for more than ten years. His local doctor recommended lamivudine treatment, and after one year of lamivudine resistance, he was referred to our hospital. I advised him to take lamivudine combined with adefovir treatment, which was very effective, with the virus turning negative after three months, and the liver function continued to be normal thereafter. After three months, the virus became negative and his liver function continued to be normal thereafter. After five years of lamivudine and adefovir treatment, Brother Lin’s viral load rose to four-tenths of a copy, and the drug-resistance locus test showed that lamivudine and adefovir were both drug-resistant. Brother Lin took the lab results and said to me sadly, “Now that the virus is drug-resistant, haven’t I been taking the medication for the past five years for nothing? Alas, the former work is wasted!” Is it really a waste of effort? I don’t think so. During the five years of Lamivudine and Adefovir treatment, his viral load was consistently below the lower limit of detection, his liver function was consistently normal, and he worked and lived as healthily and happily as a normal person, and his liver function was still normal even though he is now drug resistant. Five years of combined antiviral therapy in exchange for five years of health and peace, how can it be written off because of drug resistance? How can we say that we have wasted our efforts just because of drug resistance? I advised Brother Lin to switch to tenofovir plus entecavir immediately. Two months later, his viral load was below the lower limit of detection, but his AST elevated to over 150. By six months of tenofovir plus entecavir treatment, all liver functions had returned to normal, the drug resistance storm had subsided, and Brother Lin resumed his quiet life. Currently, there are two major categories of oral anti-hepatitis B virus drugs, five in total. As long as the medication is standardized, most of the drug resistance can be avoided, and even if drug resistance occurs, it can be completely controlled. Tenofovir is the strongest antiviral drug at present, the resistance rate is zero, and it can almost “take” all the drug-resistant virus strains. Drug resistance is not scary, and after drug resistance, it is by no means the end of the road, the key is to standardize the use of medication and reasonable response.