Patients who need to take tenofovir and develop cirrhosis usually have hepatitis B followed by cirrhosis. The treatments for cirrhosis after 5 years of tenofovir include general treatment, drug treatment, and surgical treatment. 1. General treatment: avoid taking drugs with hepatotoxicity, such as gentamicin, kanamycin and so on. 2. Drug treatment: continue to take tenofovir to treat hepatitis B. Reduced glutathione, adenosylmethionine and other hepatoprotective drugs can also be used, and furosemide, spironolactone and other diuretic drugs can be used to treat the symptoms of ascites. 3. Surgical treatment: the main transjugular vein portosystemic shunt, reduce portal pressure, play the purpose of treatment of esophagogastric fundal varices rupture bleeding. Patients who appear to have cirrhosis after taking tenofovir for 5 years should standardize the treatment under the guidance of the doctor.