Whether the total bilirubin of 25.1 umol/L is serious or not is related to the cause of its elevation. If the elevation of bilirubin is caused by physiological reasons such as drinking alcohol or staying up all night, the elevation will return to normal after the removal of the triggering factors, and therefore it is not serious. If the total bilirubin is elevated due to viral hepatitis, intrahepatic bile duct stones, hemolytic anemia, etc., timely treatment is needed. The normal value of total bilirubin in serum is 1.7-17.1umol/L. Total bilirubin of 25.1umol/L belongs to the range of mild elevation, and the causes of elevation are physiologic and pathologic, as follows. 1. Physiological reasons: if the total bilirubin is mildly elevated due to late night, alcohol consumption, fatigue, strenuous exercise, etc., the total bilirubin can be returned to normal after removing the triggering factors by improving the life style and quitting alcohol consumption. 2. Pathological causes: If the total bilirubin is mildly elevated due to viral hepatitis, intrahepatic bile duct stones, hemolytic anemia and other pathological causes, although the elevation of total bilirubin is not obvious, attention should be paid to it and standardized treatment should be carried out. There are many reasons for high total bilirubin, so it is recommended to carry out standardized treatment after consulting a doctor to clarify the cause of the disease, and not to judge the severity of the disease on your own, so as not to cause adverse effects.