FDA-approved indications for growth hormone 1. growth hormone deficiency (1985) 2. chronic renal insufficiency prior to renal transplantation (1993) 3. HIV infection-related failure syndrome (1996) 4. Turner syndrome (1996) 5. adult GH replacement therapy (1997) 6. Prader-Willi syndrome ( Idiopathic short stature (2003) 9. Short bowel syndrome (2003) 10. SHOX gene defect in children without GHD (2006)