Cushing’s syndrome does not heal on its own. Cushing’s syndrome is caused by increased secretion of cortisol in the blood due to various reasons. The causes of Cushing’s syndrome include the following: a. Pituitary lesions, such as pituitary tumors or pituitary hyperplasia, which increase the secretion of adrenocorticotropic hormone, or ACTH, leading to excessive secretion of cortisol secondary to the adrenal cortex. Second, lesions of the adrenal gland itself, such as adrenal adenoma, adrenal cancer, adrenal hyperplasia, etc., can cause excessive cortisol secretion from the adrenal cortex, leading to Cushing’s syndrome. Ectopic ACTH syndrome. Normally, ACTH is secreted by pituitary gland, but tumors in certain areas, such as lung cancer, may secrete ACTH ectopically, which may also promote increased secretion of cortisol by adrenal cortex, causing ectopic ACTH syndrome. Fourth, Cushing’s syndrome caused by exogenous hormones, the symptoms of this category will be improved to some extent after discontinuing the use of hormones. Therefore, diseases that commonly cause Cushing’s syndrome, such as pituitary lesions, adrenal lesions, and malignant tumors in other parts of the body, will not heal on their own, and Cushing’s syndrome will not heal on its own.