For virus-induced mononucleosis, asymptomatic patients can be reviewed regularly, while symptomatic patients need to actively search for the cause and antiviral treatment. 1. Asymptomatic: When viral infection occurs, the mononuclear phagocytosis system is activated, and the peripheral blood mononuclear cells increase accordingly. Since most viral infections are self-limiting, rest can be taken care of and no special treatment is needed if there are no symptoms, but regular blood tests should be conducted to check the changes of monocytes. 2. Symptomatic patients: If there are fever, sore throat, liver and spleen enlargement, and abnormal lymphocytes in the blood, it is necessary to actively search for the type of infected virus and actively treat the symptoms with antiviral therapy, and bone marrow aspiration is needed to find out whether there is any combination of hematologic diseases. Note: Viral mononucleosis requires multidisciplinary follow-up in hematology and infectious diseases. If you feel unwell, consult a doctor promptly.