It is difficult to judge whether patients with advanced liver cancer can wake up from coma or not, there are individual differences, and most of them are difficult to wake up, but some of them can be woken up after comprehensive treatment. Hepatic coma caused by advanced hepatocellular carcinoma has irreparable damage to liver function, poor prognosis, rapid progression of disease and short survival time, and it is difficult to wake up in most cases. However, there are individual differences, and some patients have a chance to wake up after their condition is controlled through active comprehensive treatment, such as lactulose enema, Mentholatum ornithine sedation and artificial liver. Liver cancer is highly malignant and difficult to treat. Once diagnosed, it is recommended to treat it actively to avoid rapid development of the disease and adverse consequences.