Generally, omeprazole and propafenone can be taken at the same time. Omeprazole belongs to proton pump inhibitors, which can inhibit gastric acid secretion, reduce the damage of gastric acid to the mucosa of the upper gastrointestinal tract in the state of disease, improve the symptoms of epigastric pain and acid reflux, and promote the healing of mucosal ulcers and erosions. It can also improve the efficacy of antibiotics against Helicobacter pylori by reducing intragastric acidity, and also create conditions for hemostasis of upper gastrointestinal bleeding. Propafenone is a broad-spectrum anti-arrhythmic drug, which is mainly used for the prevention and treatment of arrhythmia, and can effectively alleviate the symptoms of panic and palpitations caused by arrhythmia. It is contraindicated in severe heart failure, severe cardiogenic shock, severe conduction block without pacemaker implantation, severe hypotension, and allergy to Propafenone related drugs. Both of the above drugs should be used under medical supervision.