The toothache is mostly caused by insufficient kidney yin, and can often be treated with Liu Wei Di Huang Pill, Zhi Bai Di Huang Pill, etc. It is recommended that the physician guide the specific use of medication after an interview. The symptoms of toothache are vague pain in the teeth, gums slightly red and swollen, can be accompanied by gum recession, loose teeth, chewing weakness, pain in the afternoon or night aggravation, lumbar and knee pain, dizziness, dry mouth and tongue, tinnitus, spermatorrhea, etc., the treatment of nourishing yin, beneficial to the kidneys, the method of lowering the fire to relieve the pain. Six-flavored Di Huang Pill is good at treating yin deficiency and fire (deficiency of yin and essence in the body, resulting in hyperactive fire), and it can improve the swollen gums and pain caused by insufficient kidney yin, dry mouth and tongue, etc. If the deficiency fire is more serious, Zhi Bai Di Huang Pill can be chosen to clear the heat even more. The adverse reactions and contraindications of the two drugs are not clear. Patients with deficiency fire toothache need to be treated under the guidance of a physician to identify the evidence, and should not take medication on their own.