Glucocorticoid-dependent dermatitis is a type of dermatitis caused by repeated inappropriate use of topical hormones over a long period of time. The manifestation of glucocorticosteroids after the disappearance of primary skin lesions, but after stopping the use of glucocorticosteroids again appeared inflammatory damage, the need to repeat the use of glucocorticosteroids in order to control the symptoms and gradually aggravate a kind of dermatitis. In recent years, the incidence of this disease has been on the rise year by year, and it is stubborn and difficult to cure. Hormone-dependent dermatitis causes 1, the wrong choice of indications Corticosteroid hormones have inhibited the immune response to the anti-allergic effect of external use can reduce congestion and edema, so that the degree of itching and inflammatory reaction of some skin damage to temporarily alleviate and subside, people tend to be confused by this illusion, coupled with the misleading advertising, and many people on the scope of hormone application and lack of understanding of the adverse effects of long-term abuse, resulting in adverse consequences. This has led to adverse consequences. There are also a very small number of people, still using cosmetics similar to the drug, such drugs will only make our face appear hormone-dependent dermatitis only, will not be good for us. Some also misinterpret the “anti-inflammatory” effect of corticosteroids as the anti-inflammatory and antibacterial effects of antibiotics and abuse them repeatedly and inappropriately over a long period of time. For example, common skin diseases such as acne, seborrheic dermatitis, ringworm, impetigo and other bacterial and fungal infections, eczema, dermatitis and other allergic skin diseases. Especially occurring in the face, pubic dermatosis long-term large-scale use of stronger hormone preparations, because these parts of the skin corticosteroids are more easily absorbed, side effects are also relatively easy to occur; it is easy to cause skin atrophy, thinning, capillary dilation, pigmentation spots, skin wrinkled aging. Especially infants and young children, their skin is very delicate, for these medicinal products are very sensitive, if the long-term use of words, will only cause the child to appear serious adverse consequences. 2, improper choice of drug varieties Corticosteroid hormone potent preparation, the most likely to cause skin atrophy and other side effects, but due to the arbitrariness of the user, this type of drug was abused. Experiments have shown that, in the dermatological king cream, dermatitis flat cream, skin light cream, spot cream, beclomethasone cream, compound Connor Le cream, skin cream of these seven types of drugs, to the monthly per capita dosage calculation, dermatological king cream per capita dosage of the least, but the proportion of the side-effects caused by as high as 60.4%, one of the reasons is that the drug contains the strongest potent preparation clobetasol, and this characteristic is not for the user to understand. 3, the use of drugs for too long Short-term topical corticosteroids can cause epidermal atrophy and can inhibit the synthesis of dermal collagen, long-term large-scale external use can cause systemic side effects. Experiments have shown that long-term use of drugs lead to weakening of the skin barrier function, the absorption of drugs increased, forming a vicious cycle, and ultimately worsen the condition, such as a male seborrheic dermatitis patients, rotating application of a variety of corticosteroids external rub, for 14 years, in addition to the facial diversity of skin lesions and Kerhoff’s syndrome manifestations, but also occurred in the pharmacogenetic diabetes mellitus. A female chloasma patients for 3 years with daily dermatoconjugate Wang external rub, not only the facial skin side effects, and the occurrence of pharmacogenetic Cushing’s syndrome. It can be seen, even if a small area of external rubbing corticosteroids, if the time is too long, can also lead to systemic side effects. Hormone-dependent dermatitis clinical manifestations 1, epidermal and dermal thinning local long-term topical hormone, can lead to a reduction in the formation of stratum corneum particles and thinning, dermal glycoproteins and proteoglycan elasticity changes in the collagen fibers to weaken the adhesion between the collagen, collagen synthesis is reduced and thinning. 2, hypopigmentation, hyperpigmentation Due to the reduction in the number of layers of the stratum corneum, the melanin that migrates to the keratinocytes is reduced, causing hypopigmentation. Hyperpigmentation may be related to the activation of melanocytes by glucocorticoids to regenerate pigment. 3, capillary dilatation Due to the weakening of adhesion between collagen fibers in the vessel wall can lead to widening of blood vessels, and the disappearance of dermal collagen leads to capillary dilatation on the surface. 4, rosacea-like, acne-like dermatitis In hormone-induced rosacea-like lesions, the density of follicular helminth mites increases significantly, helminth mites close the follicular sebaceous gland outlets, causing inflammatory reactions or metaplasia, potent hormones can also cause sebaceous gland hyperplasia, leading to characteristic rosacea-like rash. Hormones can make the epithelium of the hair follicle degenerate and degenerate, leading to the blockage of the exit, acne-like rash or aggravate the existing acne. 5, folliculitis Because of the immunosuppressive effect of hormones, it can make the local hair follicles become infected and aggravate the primary folliculitis. 6, hormone dependence and rebound phenomenon The anti-inflammatory properties of hormones can inhibit the development of papules and reduce itching, vasoconstriction, erythema disappears, however, hormones can not eliminate the cause of the disease, and after stopping the use of hormones can often cause aggravation of the original disease, which can be manifested as inflammatory edema, redness, burning sensation, discomfort, and acute pustules and other rebound phenomena. This phenomenon often occurs 2 to 10 days after the discontinuation of hormones and lasts for a few days or about 3 weeks. The rebound phenomenon causes patients to continue to use topical hormones, which results in hormone dependence. Characteristics of hormone-dependent dermatitis 1, the same part of the external use of high-efficiency corticosteroids for more than 3 weeks, skin erythema, papules, dry flaking, atrophy, atrophic lines, capillary dilatation, purpura, acne, pigmentation abnormalities, rosacea-like dermatitis, perioral dermatitis, photoallergy, hirsutism, ringworm not easily recognized, ichthyosis-like changes and other secondary symptoms. 2, after the application of the above hormone drugs, the original disease condition can be rapidly improved; once the drug is stopped, within 1-2 days, the use of the drug site skin occurrence of significant erythema, pimples, cracks, flaking, small pustules, itching and tenderness and other symptoms. When the drug is used again, the above symptoms and signs will soon subside, such as stop using, dermatitis symptoms and rapid re-emergence, and gradually aggravated, the hormone dependence is more obvious, especially to the face, vulva is common. 3, localized conscious itching or burning sensation. Hormone-dependent dermatitis treatment measures Because of Western medicine on hormone-dependent dermatitis there is no ideal therapy, mainly to take a gradual reduction in the dosage of hormone medication, coupled with antibacterial anti-inflammatory, anti-allergy drug therapy, until all the hormone medication is withdrawn, the process of treatment will take 1-2 years, the majority of patients are more difficult to accept. In the past ten years, the use of traditional Chinese medicine in the treatment of hormone-dependent dermatitis has received more significant results. Acute inflammatory period (is applying hormone drugs or stop using hormone drugs less than 1 month), with erythema, papules, capillary dilatation, swelling, burning pain, itching as the main manifestation of the person, in order to nourish yin and tonify the kidney, clearing away heat and detoxification, cooling the blood to resolve the spot, wind and stopping the itch, regulating the body’s immune system and endocrine based. Chronic stage (acute inflammation subside, stop using hormone drugs for more than a month), with erythema, cracking, flaking, small pustules, itching and tenderness as the main manifestations, treatment to nourish Yin and tonify the kidney, nourish Yin and promote the production of fluid, moistening dryness and wind, regulating the body’s immune system and endocrine. As the human body once the hormone dependence, after stopping the primary lesion rebound aggravation and secondary redness, tenderness, itching, peeling, dryness, cracks, flaking and other side effects, can make the patient to produce a greater pain, and Western medicine is generally considered hormone-dependent dermatitis treatment is more tricky, its treatment program is to antibacterial agents, vitamins and desensitizing drugs at the same time, continue to use hormone therapy, gradually reduce the amount to the withdrawal of the discontinuation. The treatment program is to use antibacterial, vitamin and desensitizing drugs, continue to use hormone drug therapy, gradually reduce the amount to withdraw and stop. It takes more than one year for the lesions to return to normal, and most of the patients have a lot of mental stress. In this regard, doctors and patients’ families should do a good job of patients’ ideological work, the role of hormones and side effects to have a full understanding, and enhance their confidence in overcoming the disease. And in the correct choice of therapeutic drugs and gradually reduce the amount until the withdrawal of corticosteroids, the use of traditional Chinese medicine to combat the above side effects and adverse reactions.