Differential pressure greater than 80 mm Hg should be identified in the hospital, and different treatment measures, usually including medication and surgery, should be taken for different causes. A differential pulse pressure greater than 60 mm Hg is considered an increased differential pulse pressure. Common causes of differential pulse pressure include hypertension in the elderly, which is characterized by high systolic blood pressure and low diastolic blood pressure. Diuretic antihypertensive drugs such as indapamide and dihydroclonidine can be prescribed to lower blood pressure. Hyperthyroidism can lead to increased pulse pressure difference, complete the thyroid function triple test can confirm the diagnosis, take antithyroid drugs, methimazole treatment. Severe anemia will lead to increased pulse pressure difference, improve the routine blood test, severe anemia needs blood transfusion treatment. Improve the anemia screening, anemia triple test, rheumatism and immunity, gastroenteroscopy, bone marrow examination, etc., to clarify the cause of anemia, and treatment for the cause of anemia. Severe aortic valve insufficiency can lead to an increase in the pulse pressure difference, which can be reduced by replacing the aortic valve. If the pulse pressure difference is found to increase, it is necessary to go to the hospital to improve the blood pressure monitoring, AF3, blood routine, cardiac ultrasound and other tests to clarify the cause of the disease and targeted treatment.