Lung nodules with hairy edges and clear boundaries are imaging findings, which may be caused by lung infections, tuberculosis, tumors, etc. Different treatments need to be given according to the corresponding diseases. 1. Lung infection: Lung infectious diseases, especially fungal infections, can lead to the appearance of single or multiple nodules in the lungs, and the imaging may show that the edges of the lung nodules are rough and the boundaries are clear, which can be treated with antifungal drugs such as fluconazole, voriconazole, amphotericin B, etc. 2. Tuberculosis: The rough edges and clear boundaries of lung nodules may also be caused by tuberculosis. Mycobacterium tuberculosis infection can cause inflammatory exudation, hyperplasia and caseous necrosis of lung tissue, manifesting destruction and repair often simultaneously. Tuberculosis patients can be treated by taking isoniazid, rifampicin and other anti-tuberculosis drugs. 3. Malignant tumors: Lung nodules with rough edges and clear boundaries may also be caused by tumors. Due to the active proliferation of tumor cells, the edges of lung nodules will be rough and clear. Tumors can be treated by surgical resection and other methods. Hairy edges and clear boundaries of lung nodules can also be caused by other diseases, it is recommended to go to the hospital in time for further examination and proper treatment under the guidance of the doctor.