Palmoplantar pustulosis, also known as palmoplantar pustulosis, is characterized by recurrent pustules on the palms of the hands and soles of the feet, which may be accompanied by erythema, scaling, itching, burning sensation and pain. Palmoplantar pustulosis lesions are confined to the palms of the hands and the plantars of the feet and are symmetrically distributed, with the palms occurring at the pisiform and petitpis interspaces, which may extend to the palms, dorsums of the hands, and fingers, and the plantars occurring at the mid-plantar and medial plantar areas. The lesions in the palmoplantar region are often symmetrical, but sometimes single lesions can occur. The areas of the lesions are grayish-red, often flaky, and the scales are removed leaving a smooth, dark red surface. Within these plaques, multiple small pustules appear. 1 to 2 weeks later, the pustules rupture, crust, and flake off, and new pustules may reappear under the scales, which may be mild or severe for a long time. The nail is often involved, and pitting, transverse grooves, longitudinal ridges, turbidity of the nail, nail peeling, and pus accumulation under the nail may appear. Patients with palmoplantar pustulosis may have itching and burning sensations in the lesions, and repeated scratching may induce skin bleeding. The disease may also be associated with thyroid dysfunction and different types of arthropathy. If the clinical symptoms of palmoplantar pustulosis appear, it is recommended that the patient consult a doctor in time and standardize the treatment under the guidance of the doctor, so as to avoid delaying the condition.