Patients with breast nodules during menopause cannot take estrogen supplements if they are not particularly deficient in estrogen. The presence of breast nodules is generally related to an imbalance in the level of ovarian endocrine hormones. The relationship between sex hormones and breast nodules lies mainly in the fact that sex hormones play a dominant role in the development and pathological changes of the mammary glands. Estrogen promotes the growth of fibrous tissue in and around the milk ducts, and progesterone has a stimulating effect on the development of lobular and alveolar tissue in the mammary gland. The structure of breast tissue under normal circumstances will change with the hormone levels of the menstrual cycle, and physiological hyperplasia will generally occur before the onset of menstruation and return to normal after menstruation. If estrogen is supplemented during menopause, it may disrupt normal hormone levels or cause excessive estrogen. When there is an imbalance between luteinizing hormone and estrogen in the body, it will easily lead to disruption of the tissue structure. When estrogen is too high, the tissues associated with the breast are more likely to develop hyperplasia or cysts. Patients are advised to go to the hospital for checkups, and if there is a serious lack of estrogen in the body, supplementation can be done under the guidance of the doctor.