The emergence of ascites in pancreatic cancer suggests that it enters the advanced stage of the disease, and the survival time is generally three to six months, which can be improved by radiotherapy, targeted therapy and drainage through abdominal puncture. Clinical chemotherapeutic drugs for treating pancreatic cancer include cisplatin, cyclophosphamide, paclitaxel and so on; targeted drugs include imatinib, bevacizumab and so on. They can effectively control tumor proliferation and metastasis and improve the quality of life of patients. The drugs need to be used in accordance with the doctor’s instructions, the emergence of adverse reactions promptly seek medical treatment, drug allergy is prohibited. In addition to medication, ascites can also be extracted by abdominal puncture to relieve discomfort and improve symptoms. Therefore, it is recommended to actively cooperate with doctors to receive standardized treatment after ascites appears in pancreatic cancer, so as to prolong the survival time of patients and improve the prognosis of the disease.