The contribution of classical gram in the field of treatment of inflammatory bowel disease is certain, and some people always think that classical gram treatment is perfect, just more expensive. However, after reading a lot of patients who not only did not benefit but also suffered from side effects, I had to scientifically explain the following. I hope that patients who have been injected with analogs think of the following when they have discomfort! Affirmation: As a doctor, it is your responsibility to inform and educate about the good and bad of various treatment drugs and modalities! This knowledge was originally public, but it was originally in English, so I’m just relaying it here! How many of you know or have been told about the “problems with classical grams for inflammatory bowel disease” I hope the following information (the latest consensus opinion in the US) will be of benefit to you: 1. Infection complications: 4% of serious infections have at least a 2-fold increased risk of infection; 2. Tuberculosis infections have a 50-90-fold increased risk; 3. Fungal infections have an increased risk; 4. 4. increased viral infections; 5. increased multifocal leukoencephalopathy; 6. malignancy; 7. high risk of non-Hodgkin’s lymphoma; 8. lymphoproliferative disorders; 9. hepatosplenic T-cell lymphoma; 10. tumor recurrence; 11. immunogenicity and tolerance deficits; 12. increased delayed anaphylactic reactions; 13. other: increased heart failure, dermatitis