Selenium supplementation can improve the symptoms of rheumatoid arthritis, but the key is the need for regular medication. Rheumatoid arthritis is an autoimmune disease, which is mainly characterized by symmetrical polyarthritis. A foreign experiment showed that the selenium content in the body of patients with rheumatoid arthritis is significantly lower than that of normal people, after selenium supplementation, the patient’s pain symptoms are reduced, and the delayed onset of allergic skin experiments have also improved significantly. In addition to selenium for rheumatoid arthritis symptom relief, but also to use rheumatoid regular treatment methods, including general management and drug treatment. General treatment is based on braking and resting, and common therapeutic drugs include non-steroidal anti-inflammatory drugs such as celecoxib, glucocorticosteroids such as prednisone acetate tablets, traditional DMARDS such as leflunomide, methotrexate, etc., and biologics such as tolizumab. It is recommended that patients with rheumatoid arthritis consult the rheumatology and immunology department in a timely manner, for the treatment of rheumatoid arthritis should follow the doctor’s instructions, combined treatment, not only focus on selenium supplementation.