Hepatitis B surface antigen thirteen point several, mostly suggests that there is chronic hepatitis B, can not be based on the results of this test alone to determine whether it is serious, need to be combined with the hepatitis B five, liver function, viral quantification, liver ultrasound to determine, if the liver function and liver ultrasound is normal, then it is a carrier of the virus, is not serious, if the development of cirrhosis, liver cancer, etc., then it is more serious. 1. Chronic hepatitis B: If it is only chronic hepatitis B and the liver function is not affected, it is usually not serious. If the liver function is abnormal, or there is histological damage of the liver can be controlled after regular treatment. However, if it is not treated in time, the disease progresses and may develop into cirrhosis and liver cancer, which are more serious. 2. Cirrhosis: the disease is more serious, but the survival rate of most patients can be improved after liver transplantation, which can effectively relieve the condition. If the treatment is not timely or delayed, it may develop into liver cancer and easily cause liver failure. 3. Hepatocellular carcinoma: It is a malignant tumor of liver and its condition is more serious. However, if it is early liver cancer, timely radical surgery can delay the progress of the disease and improve the quality of life. If the disease is delayed, the patient will have the risk of death at any time. Hepatitis B surface antigen 13.0 or so should be combined with other 4 items of Hepatitis B five tests (including Hepatitis B surface antibody, Hepatitis B e antigen, Hepatitis B e antibody and Hepatitis B core antibody), liver function, liver ultrasound and other diagnostic analyses. If cancer is suspected, it is necessary to do a liver biopsy and puncture, and then according to the cause of the targeted treatment.