There are many possible clinical causes of swollen lymph nodes in the feet, mainly due to various types of infections, connective tissue diseases and malignant tumors. 1. Infectious diseases: this is the most common cause of enlarged lymph nodes in the feet, when the skin of the feet is infected and produce local inflammatory reaction, it will cause stimulation to the surrounding lymph nodes and make them enlarged. 2. Connective tissue disease: this is a multi-system, multi-organ involvement of autoimmune diseases, usually associated with heredity, viral infections, immune system abnormalities and other factors, when the foot tissues of rheumatoid arthritis, tuberculosis and other connective tissue diseases, will cause stimulation of the surrounding lymph nodes and swelling. 3. Malignant tumor: Lymphoma, lymphoblastic leukemia, bone cancer, lung cancer, liver cancer and so on are common in clinic, which will cause lymph node enlargement in feet through lymphatic transfer or distant transfer in blood circulation. If you find enlarged lymph nodes in your feet, it is recommended to go to the hospital in time, complete the examination, clarify the cause of the disease and follow the doctor’s instruction to carry out targeted treatment.