Hepatitis B surface antigen positive with low core antibody indicates infection with hepatitis B virus. The presence of hepatitis B surface antigen positive and low core antibody indicates that the patient has been infected with hepatitis B virus, suggesting early acute HBV infection, latent acute HBV infection or chronic HBV carrier. 1. Hepatitis B virus surface antigen: Hepatitis B surface antigen is the shell protein of hepatitis B virus, which is the sign of hepatitis B virus infection. The appearance of hepatitis B virus surface antigen indicates acute hepatitis B, chronic hepatitis B patients or hepatitis B virus carriers. Most of the acute hepatitis B patients can turn negative early in the course of the disease, while the surface antigen of chronic hepatitis B patients or virus carriers can be positive continuously. 2. Core antibody: Hepatitis B core antibody often indicates previous infection with hepatitis B virus. If the results of Hepatitis B five tests are abnormal, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment or therapy with the help of a doctor.