There is no clinical research proving that advanced anal canal cancer can be cured. Whether or not anal canal cancer can be cured in the late stage is related to many factors, such as the degree of tumor lesions, the patient’s physical quality, the treatment means, etc., the specific situation cannot be generalized. Anal canal cancer refers to tumors originated from or mainly located in anal canal, the cause of which is still unknown, and may be related to anal fistula, warts, etc. Symptoms can be seen as anal pain, anal itching with secretion, and so on. Clinical treatments for anal canal cancer are mainly radiotherapy, chemotherapy and surgery when necessary. For patients with advanced stage of anal canal cancer, radiotherapy and chemotherapy are mainly synchronized to achieve the purpose of preserving the anus and improving the survival rate and quality of life of patients. Patients with anal canal cancer can minimize the adverse effects of the disease through “early detection, early diagnosis and early treatment”, and many of them can survive for a long time, so it is suggested that patients should establish confidence in treatment. If diagnosed with advanced anal canal cancer, patients should go to the hospital in time for relevant examinations to clarify the degree of disease progression, formulate treatment plans after evaluation, and actively cooperate with doctors’ treatment.