Hepatitis B virus greater than 5.000E+07 requires treatment. Hepatitis B virus, i.e., hepatitis B virus DNA titer greater than 5.000E+07U/ml, meets the indications for antiviral therapy in both acute and chronic hepatitis B. In acute hepatitis B, hepatitis B virus DNA greater than 2000 U/ml is eligible for antiviral therapy. In chronic hepatitis B, hepatitis B core antigen positivity and hepatitis B virus DNA greater than 20,000 U/ml; hepatitis B core antigen negativity and hepatitis B virus DNA greater than 2,000 U/ml are eligible for antiviral therapy. Hepatitis B virus titer is high, in addition to the need for antiviral (such as entecavir) treatment, should pay attention to rest, with liver function impairment, and be given to protect the liver (bisabolol), reduce yellow (ursodeoxycholic acid) and other symptomatic treatment. All the drugs mentioned should be taken under the guidance of a doctor, and should not be used at will. If you feel sick, consult a doctor for early treatment.