Blood group incompatibility refers to the occurrence of hemolytic disease in patients in clinical transfusion and obstetrics due to ABO blood group incompatibility or Rh blood group incompatibility. Blood group incompatibility in newborns is prone to neonatal hemolysis due to maternal-infant blood group incompatibility, especially when the mother has O blood type and the fetus has A or B blood type. During pregnancy, a small amount of fetal red blood cells may enter the mother’s body through the umbilical vein and stimulate the mother to produce antibodies, which may enter the newborn’s body during delivery, resulting in hemolysis of the mother’s blood type. Another situation is that during clinical transfusion, when blood of the wrong blood type is mixed together, a serious hemolytic reaction can occur, resulting in a series of symptoms such as chills, chills, and high fever in the patient. Often, the treatment of emergency cases requires immediate stopping of blood transfusion, as well as rehydration of the patient to maintain urine volume, preserve kidney function, and in severe cases, anti-shock treatment.