Patients with congenital atrial septal defects without clinical symptoms and cardiopulmonary problems may be considered for vaccination with the New Crown vaccine. However, vaccination is not recommended for patients with severe cardiopulmonary problems such as palpitations and wheezing with heart failure and arrhythmias. It needs to be considered in the context of the patient’s own condition. 1. Congenital atrial septal defect is a congenital heart malformation disease, the cause of which is mostly due to abnormal embryonic development. There may be no obvious clinical manifestations in the early stage, and most children are prone to upper respiratory tract infections and other symptoms. Most children are prone to symptoms such as upper respiratory infections. In young people, the disease manifests itself as palpitations, shortness of breath and fatigue, etc. Arrhythmias and heart failure may worsen after the age of 40. 2. Contraindications to vaccination are acute illnesses and uncontrollable severe chronic diseases. Therefore, vaccination is not recommended when there are clinically relevant symptoms of congenital atrial septal defect with abnormal cardiopulmonary function. Vaccination should be considered after the condition is stabilized. Whether or not to vaccinate should take into account the patient’s current condition. It is recommended to go to a regular vaccination site or hospital for consultation and evaluation by a medical professional.