What are the timing options for mother-to-child blockade for hepatitis B? Pre-pregnancy blockade; Pregnancy blockade; Post-birth blockade Just do healthy carriers of hepatitis B still need to have mother-to-child blockade? All patients with hepatitis B need postnatal blockade, but most patients do not need preconception or pregnancy blockade. What kind of patients are suitable for preconception blockade? Preconception blockade and preconception treatment for hepatitis B patients are different concepts, although the medications applied may be the same, as there are no established preconception blockade regimens and the various treatment options of preconception blockade are not recommended for healthy carriers with low viral loads. For patients with high viral load hepatitis B preconception interferon therapy may be the most promising drug for preconception blockade. It may be considered for application after weighing the pros and cons. What kind of patients are suitable for pregnancy blockade? Patients with HBV-DNA ≥ 106 IU/ml are all patients who may require pregnancy interruption. The starting time of drug application needs to be judged based on a combination of circumstances, including liver function and whether nucleoside analog antiviral drugs have been used before pregnancy. Are there risks associated with antiviral therapy during pregnancy? There are risks associated with antiviral therapy during pregnancy, but in patients with high viral load with abnormal liver function, the application of antiviral therapy will reduce adverse events during pregnancy and delivery. For patients taking the drug solely for maternal-infant blockade, the use of pregnancy-graded class B antivirals in late pregnancy does not increase the rate of birth defects. In addition the adverse effects of the drugs are mild and can be tolerated by most patients. Does the newborn necessarily become infected without antiviral therapy? No antiviral treatment only increases the probability of hepatitis B infection in the newborn. For mothers with high viral load, the probability of hepatitis B infection in the newborn is about 30%, and this probability of infection can be reduced to less than 5% with antiviral treatment. What are the options for proposed nucleoside antiviral therapy during pregnancy? Currently, the drugs that can be considered for pregnancy class B are tipifudin and tenofovir. In addition, lamivudine, a pregnancy class C drug, is also considered to be an antiviral drug of choice during pregnancy, given the clinical safety studies in a large number of pregnant women. Is hepatitis B immunoglobulin effective during pregnancy? The definitive answer to this question is that there is no reliable medical evidence to support its effectiveness, especially in mothers with high viral loads. It is currently believed that hepatitis B immunoglobulin is less effective as a blocker of vertical transmission of HBV during pregnancy and is not suitable for very common use in mothers with hepatitis B, as previously thought. However, further studies are needed to find markers for this specific population. Do I have to keep taking antiviral drugs during pregnancy? No. For those who are taking nucleoside analogues for the sole purpose of mother-to-child interruption, long-term use of antiviral drugs is not necessary. Can I breastfeed on antiviral drugs? The current answer is no, but no significant adverse events have been found in studies of lamivudine breastfeeding in HIV patients. Therefore, for families with poor economic conditions who really have difficulty in artificial feeding, breastfeeding can be considered along with lamivudine.