Pre-conception checkup is a series of checkups for couples preparing for pregnancy.1. For female checkups, we recommend vaginal ultrasound, gynecological examination, vaginal secretions, eugenics, infectious markers, and thyroid function, etc. At present, the incidence of thyroid disease in China is high, and abnormal thyroid function has a significant impact on fertility. At present, the incidence of thyroid disease in China is very high, and abnormal thyroid function has a significant impact on fertility, so the patient will be recommended to carry out pre-pregnancy thyroid examination, such as other ultrasound, vaginal secretions and gynecological examination, mainly to check the presence of uterus and bilateral ovarian abnormalities, such as the presence of uterine fibroids, ovarian cysts, and the reserve of the follicles of the bilateral ovarian sinus. Gynecological examination and secretions are mainly to rule out the presence of pelvic and reproductive tract inflammation, these aspects of the abnormalities will have an impact on the pregnancy; 2, the male partner mainly semen routine, urethral secretions, infectious markers of the examination, these tests can be found in advance of the possible factors affecting the preparation for pregnancy, such as the male partner’s semen abnormality, oligo-weak spermatids, deformed spermatids, poor liquefaction and so on in advance of the man-made interventions. If there are abnormalities in the infectious markers, such as Hepatitis B, Syphilis or HIV, further tests and treatment will be carried out to avoid detection of these problems during pregnancy, which can be more reactive.