Nicorandil has no claims of maximum side effects, possible adverse reactions include headache, dizziness, tinnitus, and insomnia. Nicorandil belongs to the class of nitrate compounds, which can prevent intracellular calcium ions from freeing to the outside of the cell after use, and can also increase the permeability of the cell membrane to potassium ions, thus dilating coronary artery blood vessels, continuously increasing the flow of coronary artery blood, as well as inhibiting coronary artery spasm. It is mainly used in the treatment of coronary heart disease, angina pectoris and other diseases. Usually the drug will cause headache, dizziness, tinnitus, insomnia and other discomforts after taking it, and aspirin can alleviate the related symptoms after taking it. It may also cause diarrhea, abdominal pain, palpitations, fatigue and other discomforts, and is contraindicated for people with glaucoma, severe liver and kidney impairment. In the process of taking the drug, it is necessary to pay attention to monitoring blood pressure and liver and kidney function, and to follow the doctor’s instructions to avoid overdose and cause hypotension. If it is necessary to use with other drugs, it is recommended to decide after a comprehensive assessment of the condition by a doctor, and pregnant and lactating women need to use the drug under the supervision of a doctor. Nicorandil should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.