Low back pain is one of the early symptoms of kidney cancer, and mass is also one of the common early symptoms of kidney cancer. Low back pain is often caused by the growth of the mass and swelling of the kidney peritoneum, while blood clots passing through the ureter can also cause low back pain as mentioned above. When the tumor of kidney cancer invades the surrounding organs and lumbar muscle, the pain is more severe and persistent. Since the kidney is hidden, it is difficult to detect the mass until the kidney cancer reaches a large size. Generally, it is already an advanced symptom when a lump is felt in the abdomen. Chained multicellular bioimmunotherapy avoids the drawbacks of surgery and radiotherapy for cancer patients, such as surgery recurrence or radiotherapy will bring relative side effects to human body. Biological therapy is safe without side effects and can repair the damaged tissues after surgery and radiotherapy to prevent recurrence and metastasis. Early manifestations 1. Hematuria: Hematuria is often painless and intermittent, and the whole process of hematuria is visible to the naked eye, and the intermittent period is shortened with the development of the disease. When kidney cancer bleeds a lot, it may be accompanied by renal colic, which is often caused by the passage of blood clots through ureter. The blood clots in hematuria of kidney cancer may be formed in strips by passing through the ureter. The degree of hematuria is not related to the size of the kidney cancer. Sometimes, kidney cancer may manifest as persistent microscopic hematuria. 2.Lower back pain: Lower back pain is another common symptom of kidney cancer, mostly dull pain, which is confined to the lower back. The pain is often caused by the growth of the mass and swelling of the renal peritoneum. When the tumor invades the surrounding organs and lumbar muscle, the pain is more severe and persistent. 3.Lumps: Lumps are also a common symptom. About 1/3-1/4 of kidney cancer patients can find enlarged kidney when they visit the doctor. Since the kidney is hidden, it is difficult to detect the mass until the kidney cancer reaches a large size. Generally, it is already an advanced symptom when a lump is felt in the abdomen. Pain: Pain is seen in about 50% of cases and is also a symptom of advanced stage. It is caused by the persistent pain in the affected side of the back due to the tumor invasion and compression of connective tissue, muscles, lumbar vertebrae or lumbar nerves in the posterior abdominal wall or the renal pelvis. 5. Other symptoms: unexplained fever, or metastasis when first detected, lung symptoms such as weakness, weight loss, loss of appetite, anemia, cough and coughing up blood. In addition, the effects of renal adenocarcinoma are caused by the endocrine activity of the tumor, including erythrocytosis, hypertension, hypotension, hypercalcemia, and fever syndrome. Although these systemic, toxic and endocrine effects are non-specific, about 30% of patients first have many mixed manifestations. Thus it is a valuable clue that such findings are considered as a systemic effect of the tumor.