The most effective sleeping drugs in clinical practice are non-benzodiazepine sedative sleeping drugs, including zopiclone, dezopiclone and zolpidem. These drugs not only have a rapid onset of action, induce sleep rapidly, and can significantly improve symptoms such as difficulty falling asleep and sleep maintenance disorders. Moreover, these drugs are metabolized quickly, and there are no side effects such as drowsiness and mental lethargy in the next morning, and there is no obvious drug dependence or rebound phenomenon when the drugs are stopped, especially for students, people working at height, drivers and other occupations have unique advantages, so these drugs are currently used as the first-line drugs for the treatment of insomnia. In addition, tranquilizers, melatonin, anti-anxiety drugs, antidepressants and herbal medicines also have a role in improving sleep. However, the efficacy and side effects are lacking compared to non-benzodiazepine sedative sleeping drugs, so there are some limitations in clinical use.