Kidney cysts may cause creatinine increase, kidney cysts are firstly divided into congenital and acquired kidney cysts, acquired kidney cysts usually do not cause creatinine increase, but larger cysts may cause creatinine increase. Congenital hereditary renal cysts, i.e. polycystic kidney, may also cause creatinine increase. Kidney cysts that are not more than 5 centimeters and do not affect the normal function of renal tissues usually do not cause creatinine elevation because most of the acquired renal cysts are benign and usually do not have too much effect on the health of the body. However, if the cysts are relatively large and show symptoms of compression or lead to hydronephrosis, it may lead to renal function impairment, symptoms such as elevated creatinine and urea nitrogen; most patients with polycystic kidney will also have renal function impairment, which will lead to creatinine elevation or even lead to renal failure. If patients have obvious clinical symptoms, they should be actively treated, and if necessary, surgical resection is feasible. Patients with renal cysts are advised to go to regular hospitals for consultation and treatment under the guidance of doctors.