There are more than five types of statin commonly used in clinical practice, the more commonly used ones are lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, resuvastatin, pitavastatin, all statins are mostly metabolized by the liver and excreted by the intestines through bile, and a small portion of them are excreted by the kidneys, so all types of statin have liver and kidney damage. All types of statin have different characteristics: pravastatin and resuvastatin belong to water-soluble statin, atorvastatin belongs to fat-water double-soluble statin, and most of the rest of statin belongs to fat-soluble statin, compared with fat-soluble statin, water-soluble statin is not easy to pass through the lipid layer of cell membrane, but it can be selectively entered into the liver cells. Therefore, water-soluble statins can selectively inhibit hepatic cholesterol synthesis and have a minimal effect on cholesterol synthesis in the adrenal glands, gonads, heart, brain, etc. In this way, they are effective in lowering serum cholesterol levels while avoiding possible effects on the liver and muscles. All statins have hepatic and renal damage, but adverse reactions are rare and mild, with occasional gastrointestinal reactions, skin flushing, headache, insomnia and other temporary reactions when applied in high doses, and occasional asymptomatic transaminase elevation, which returns to normal after discontinuation of the drug. It should be noted that this kind of drug can cause muscle adverse reactions, manifested as myalgia, myositis, rhabdomyolysis, etc. Therefore, it is recommended to use the drug under the guidance of a professional physician, and during the period of taking the drug, regular monitoring of liver and renal function is required.