Pain in the liver area at night may be gallbladder stones cholecystitis, bile duct stones, hepatitis and other diseases. 1. Gallbladder stones cholecystitis: stone disease that occurs in the gallbladder, the larger gallbladder stones can cause the upper middle abdomen or right upper abdomen stuffy discomfort, especially at night sleep pain in the liver area and other symptoms. Cholecystitis can also irritate and cause discomfort in the liver area. 2. Choledocholithiasis: a disease in which stones occur in any part of the bile ducts, most of which are asymptomatic, but the blockage of the bile ducts by the stones can cause symptoms such as biliary colic in the liver area at night. 3. Hepatitis: refers to the inflammatory disease of the liver caused by a variety of factors. Patients often show symptoms such as fatigue, loss of appetite, anorexia, nausea, and pain at night. There may be other reasons for the pain in the liver area at night, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment.