The drugs used to treat diabetic neuropathy are as follows: 1. Basic treatment: strict control of blood glucose is the basis for the treatment of diabetic neuropathy; 2. Specialist treatment: with stable blood glucose control, drugs targeting neuropathy should be used for treatment. They include nerve nutrition (methylcobalamin) antioxidant free radical drugs (lipoic acid), anti-inflammatory and analgesic drugs, dual-channel antidepressants (duloxetine), calcium channel modulators (pregabalin), etc. For patients with intractable diabetic neuralgia, short-term adjunctive application of opioids such as oxycodone and tramadol can be used to relieve pain symptoms. The specific medication should be combined with the clinical situation and guided by the doctor’s interview.