A patient has a history of diabetes for nearly 30 years and was taking metformin until a few years ago, then the medication did not work and the blood glucose remained high and was relieved after switching to insulin. But the lower extremities are not flexible, and a test was done to find moderate sensory neuropathy, which is still wound-free. What should I do to get better? First of all, although there is no wound at this time, it is an early symptom of diabetic foot, especially the loss of sensation, not feeling the external stimulation, no sensation even if there is a stabbing injury, and if the wound is not detected and treated effectively in time, the wound will be infected and become a hard-to-heal wound. Second, about the treatment of neuropathy. The mechanism of diabetic peripheral neuropathy has not been fully clarified, and the guidelines for treatment generally contain several types of therapeutic drugs such as antioxidants, aldose reductase inhibitors, microcirculatory improvers and nerve repair agents, etc. This should be based on the patient’s own situation and the development of a targeted treatment plan. Third, the treatment of their own conditions such as diabetes. Already caused by the treatment of neuropathy is one, but also like hyperglycemia, hyperlipidemia, hypertension, cardiovascular disease, renal dysfunction and so on, these own conditions have been improved after the patient will be safe. Fourth, life considerations. After the above mentioned neuropathy is particularly vulnerable to injury, life must do a good job of foot protection, try to wear cotton shoes and socks, wear new shoes to fit, to check whether there are small stones inside. Then, it is best to check both lower extremities every night, and inform the doctor of any abnormalities in time for treatment. Fifth, what about ulcers that have already appeared? Neuropathy can also affect the stretching of muscle tissue, which is not conducive to movement, and ultimately is not conducive to wound healing, and if combined with ischemia, infected wounds are more difficult to heal, and this condition should be treated early. In terms of treatment, I personally recommend the use of Chinese and Western medicine open treatment, after debridement, control of infection, improve circulation, nutrition of the wound surface and remove corrosion and muscle and other comprehensive treatment, can be conservative without amputation cure. However, I remind you that you should control your blood sugar under the guidance of your doctor since the diagnosis of diabetes to avoid complications.