Early diabetic neuropathy is manifested by numbness and tingling at the tips of the fingers and toes; some with less obvious symptoms may feel thick skin, and stepping barefoot on the ground does not feel like barefooting, but rather like a layer of skin has been spaced between. Some will feel unstable walking, especially in poor light, walking will be crooked, like drunkenness. All of these may be diabetic peripheral neuropathy. Another type of diabetic peripheral neuropathy is “neuralgia”. Patients may feel like they have been electrocuted all day long in the tips of their fingers, toes, palms, feet, backs of their hands, and feet, and this feeling may be worse at night, in too hot or too cold weather. The manifestations of diabetic peripheral neuropathy are colorful and varied. Every diabetic patient should have a complete examination by a neurologist to get the right treatment. The treatment of diabetic neuropathy can be divided into two levels, the first level is the control of diabetes, NTUH and studies around the world, all show that the level of blood sugar is directly related to the occurrence of diabetic neuropathy, good control of blood sugar can delay the occurrence of complications of diabetes, including neuropathy, so detailed consultation and treatment by a pain specialist is necessary. Secondly, symptoms such as “neuralgia” and numbness caused by diabetic neuropathy can be evaluated in detail by a pain specialist. Therefore, when you know you have diabetic neuropathy, don’t be discouraged and don’t take it lightly, consult a diabetic and pain specialist. Treatment of diabetic neuropathy is divided into general treatment and specific treatment. General treatment includes controlling blood glucose, blood pressure and blood lipids in normal range; avoiding high blood glucose fluctuating too much in a short period of time, abstaining from smoking and alcohol; choosing appropriate medications, such as methylvitamin B12 (Micropol), Pepeda, Kaiser, nimodipine, nerve growth factor, aldose reductase inhibitors, inositol, etc. Treatment of painful diabetic neuropathy is very difficult and can be treated with topical application of capsaicin and oral administration of drugs such as carbamazepine, promethazine, amitriptyline, doxorubicin, and phenytoin sodium. Sometimes none of the above treatments work well, but the symptoms of diabetic neuropathy will resolve on their own. Treatment of diabetic autonomic neuropathy varies depending on the clinical manifestations. In case of diarrhea, Emmentaler and Colistin can be used; in case of constipation, Laxative and Marenzine can be used; in case of delayed gastric emptying, morpholine, Gastroflucan and Erythromycin can be used; in case of impaired urinary emptying, lower abdominal pressure, physiotherapy and Neostigmine can be used; in case of postural hypotension, tight leggings and slow standing can be used; 9α fludrocortisone can also be used.