There are many causes of pain in the middle of the ribs, and related etiologies include intercostal neuritis, chest wall muscle soft tissue injury, pneumothorax, acute pleurisy or, hepatobiliary stones, ischemic heart disease, pancreatitis, spinal tuberculosis, and other diseases. Since a person has 12 ribs on both sides of the thorax, it includes a wide range. Pain in the middle of the ribs sometimes requires consideration of not only the skin, the muscles and nerve tissues in the middle of the ribs, but also the nearby organs, such as the ribs, liver, gallbladder, pancreas, spleen, kidney, pleura, lungs, heart, and great vessels. Because the nerves or sensory fibers innervating these tissues and organs sometimes have a crosstalk effect, they can all reflect pain at unspecified locations on the thoracic surface after a lesion occurs. Therefore, in the differential diagnosis, it is necessary to look not only at the pain in a certain location, but also in combination with other symptoms or subsequent manifestations: for example, sudden stabbing pain when a pneumothorax occurs, and then there may be discomfort such as dyspnea; for example, heart disease, stable or unstable angina, with a brief attack, which can be accompanied by regular attacks such as after labor or during exertion; and then gallstones pain The pain can be radiated to the back of the shoulder or to the surface of the chest, sometimes accompanied by nausea, vomiting, and even yellowing of the face and eyes. In summary, pain in the middle of the rib cage may be due to damage to the skin, soft tissues or ribs, or to lesions in nearby organs (such as the heart, liver, gallbladder, pancreas, spleen and kidneys).