A runny nose that doesn’t get better for a long time may be due to improper use of medication or insufficient course of treatment. This symptom may be chronic sinusitis, chronic rhinitis or allergic rhinitis, according to the different causes of the disease, the main clinical general treatment, drug treatment and surgical treatment. 1. Chronic sinusitis: bacterial infection and allergic reaction can cause this disease to occur runny nose for a long time is not good. Nasal spray with budesonide nasal spray can be used; oral clarithromycin and other macrolide antibiotics anti-inflammatory treatment. If the effect of conservative treatment is not good, endoscopic sinus surgery is feasible. 2. Chronic rhinitis: chronic simple rhinitis and chronic hypertrophic rhinitis often appear in the phenomenon of running nose for a long time. It can be treated with budesonide nasal spray; oral rhinitis tablets, Huo gall pills and other proprietary Chinese medicines. With 0.25% ~ 0.5% procaine for Yingxiang and nasal pass points closed; can also be used for the nasal mound or double inferior turbinate anterior submucosal injection. Saline nasal rinse treatment. 3. Allergic rhinitis: Repeated exposure to allergens can cause allergic rhinitis, resulting in runny nose for a long time. It can be treated conservatively by avoiding contact with allergens; standardizing the use of nasal glucocorticosteroids, such as budesonide nasal spray; taking antihistamines such as oral loratadine; and taking oral leukotriene receptor antagonists, such as montelukast sodium. Some patients who are not well treated with conservative treatment may choose to be treated with pre-sialylation nerve block and pterygoid neurotomy. Patients are advised to go to the hospital, identify the cause of the runny nose, and then follow the doctor’s instructions to standardize the use of medication and treatment.