Melanoma is a malignant disease, and the success rate of cure is related to the individual’s physical condition and the stage of the tumor. Stage 0 melanoma is confined within the skin and mucous membranes and has not invaded deeper, so removal of the entire tumor is sufficient and is usually curable. Stage I and II are limited non-metastatic melanoma. In addition to removing the tumor, nearby sentinel lymph nodes need to be biopsied to confirm that there is no metastasis and can be sutured. The cure rate of melanoma in this period is also higher. Stage III melanoma with nearby metastasis has a higher degree of malignancy, and in addition to removing the melanoma, the nearby lymph nodes should be cleared. The cure rate of melanoma in this stage is low, and interferon can be used for adjuvant treatment to reduce the probability of metastasis and recurrence. Stage IV is distant metastatic melanoma with a very high degree of malignancy. It needs to remove the distant and primary tumors, with a low cure rate and easy recurrence. For widely metastatic melanoma, conservative treatment is usually adopted. Melanoma is not sensitive to radiotherapy and is usually treated with surgery, which requires the most appropriate treatment plan under the guidance of a doctor.