The factors that cause renal tubular damage at the top of the list are toxins and drugs. The so-called toxins are exposure to some toxic substances, such as heavy metals, which are sometimes exposed to heavy metals in a variety of settings, and heavy metals can cause kidney damage. Toxic substances, such as farmers playing pesticides, but do not know self-protection, do not wear gloves, do not wear masks, and do not have any protection, so that a lot of pesticides will enter the lungs through the respiratory tract, and the lungs have a very large number of blood vessels reabsorption, leading to kidney damage. Drugs are also very important, and drug-related kidney damage should rank very high. Some of the drugs themselves have kidney damage, for example, some antibiotics themselves can cause kidney damage. Chinese herbs, such as those containing aristolochic acid, have renal toxicity and can cause kidney damage. Therefore, you should not take medicines indiscriminately, especially not substances of unknown composition, because you do not know what they contain and whether they will have drugs that damage the kidneys in them. In addition, when the kidneys are ischemic, it can lead to renal tubular damage, such as the more common heat stroke, working in the sun, sweating a lot and not replenishing water in time, which can lead to impaired kidney function and increased blood creatinine. There are also a variety of diseases that cause circulatory failure, a drop in blood pressure and kidney ischemia, which can also cause renal tubular damage, such as heart failure, the first to damage the kidneys, because the kidney vasoconstriction, poor blood supply. In short, especially stressed that patients should not take drugs indiscriminately, especially unknown ingredients or health products and so on, long-term eating sometimes unknowingly destroy the kidneys.