Squamous cell carcinoma of submandibular gland may be fatal if the disease continues to develop without active treatment. Squamous cell carcinoma of submandibular gland belongs to a group of malignant tumors with high degree of malignancy. The tumor grows rapidly and has a short course, most of which is within half a year. It can cause swelling, pain and low fever in the affected area, as well as sublingual nerve dysfunction and atrophy of tongue muscle on the affected side. The tumor may widely invade the surrounding muscles. After invading the biting muscle, it causes restriction of mouth opening. Early stage submandibular gland squamous cell carcinoma can be treated by radical surgical resection with relatively good prognosis. If it is not actively treated and develops into middle or late stage with lymph node and distant metastasis, it is difficult to be cured, and can only be slowed down by radiotherapy, targeted drugs and other methods, at which time the survival period is obviously shortened, and in serious cases, it can be life-threatening. Patients with squamous cell carcinoma of submandibular gland should actively consult the doctor and standardize the treatment under the guidance of physician to avoid delaying the condition.