Low differentiated adenocarcinoma in lung cancer is highly malignant and if not treated in a standardized way, it can progress quite fast. Some of them develop distant metastases such as cranial, bone, liver and adrenal gland at an early stage, or develop pleural effusion or pericardial effusion, which seriously affects patients’ quality of life and has a poor prognosis. It is good that there are many treatment options for adenocarcinoma, including surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy, etc. It is necessary to go to a specialized hospital for formal examination to clarify the degree of pathological differentiation and clinical stage, and then combine with the patient’s general condition to develop an individualized and standardized treatment plan, which can improve the patient’s prognosis.