Cryptogenic hepatitis B can be regularly reviewed and left untreated without onset of the disease, and if onset of the disease requires antiviral and hepatoprotective treatment. Occult hepatitis B generally refers to the hepatitis B virus replication in the body, but the patient’s liver function is normal, the interaction between the body and the hepatitis B virus is in a balanced state, and it does not affect the normal metabolism and detoxification ability of the liver. Therefore, it is recommended that patients with occult hepatitis B should have regular checkups of liver function, hepatitis B DNA, ultrasound and hepatitis B 5 to make clear the changes in their condition, and if the condition is normal or stable for a long period of time, there is generally no need for treatment. Hidden hepatitis B patients in the onset of symptoms of digestion, liver function abnormalities, such patients need active antiviral and hepatoprotective treatment, commonly used antiviral drugs such as entecavir, tenofovir, etc., hepatoprotective drugs are mainly diammonium glycyrrhizinate enteric capsule, compound glycyrrhizinate and so on. Drugs should be taken under the guidance of a physician. It is recommended to go to the hospital for further examination and treatment if hidden hepatitis is found.