Wake up in the morning to make a fist feel swelling and pain grip can not be considered tenosynovitis, rheumatoid arthritis, osteoarthritis and so on. 1. Tenosynovitis: finger flexor stenosis tenosynovitis caused by thickening of the tendon sheath, tendon sliding is not good, finger flexion and extension activities are unfavorable in the morning, flexion and extension of the popping sound, the need for minimally invasive surgery tenosynovial release. 2. Rheumatoid arthritis: symmetrical swelling of joints, morning stiffness of joints, rheumatism test can be a clear diagnosis, the application of anti-rheumatic drugs, such as prednisone or nimesulide dispersible tablets. 3. Osteoarthritis: joint hyperplasia, degeneration, narrowing of joint space, unfavorable movement of flexion and extension joints, radiographs can be a clear diagnosis, the application of anti-osteoproliferative drugs, such as Bone Fairy tablets. Wake up in the morning to make a fist feel swelling and pain can not grip tightly need to go to the hospital for further examination to clarify the diagnosis, and under the guidance of the doctor for treatment. The above drugs should be used under the guidance of a doctor to avoid self-medication.