The choice of treatment for chronic lymphocytic leukemia depends on several factors: the stage of the disease, the presence of signs and symptoms, and general health. Patients with early-stage chronic lymphocytic leukemia usually do not need to receive treatment. The following treatments are available when the indications for treatment are met, including chemotherapy, targeted drugs, immunotherapy, and bone marrow transplantation. 1. Chemotherapy: Chemotherapy is a drug treatment that kills rapidly growing cells (including leukemia cells). Chemotherapy can be given by intravenous infusion or oral medication. Doctors may use a single chemotherapy drug or a combination of drugs, depending on the patient’s condition, including cyclophosphamide and nitrogen mustard phenylbutyrate. 2. Targeted drug therapy: Targeted drugs are designed to kill cancer cells by utilizing their specific weaknesses, including Ibrutinib, Zebutinib and so on. 3. Immunotherapy: Immunotherapy refers to a treatment method that utilizes the body’s immune system to fight cancer, including clinical trials of carT cell therapy. 4. Bone Marrow Transplant: Bone Marrow Transplantation, also known as Stem Cell Transplantation, is a treatment that uses potent chemotherapeutic drugs (leucovorin, fludarabine) to kill the stem cells in the bone marrow that give rise to the diseased lymphocytes. Healthy adult hematopoietic stem cells from the donor are then injected into your own blood to rebuild the blood-forming system. These treatments can be used alone or in combination with each other, but all should be individualized under the supervision of a clinician.