1. Familial factors Congenital hereditary diseases within the family or immediate family, such as: familial cerebral palsy, degenerative diseases, mental disorders, mental retardation, familial congenital malformations, late pregnancy, frequent miscarriage, stillbirth, etc. 2, maternal factors can be divided into pregnancy factors and delivery factors. (1) Pregnancy factors (prenatal factors): delivery under 16 years old and over 40 years old, first delivery over 35 years old; habitual miscarriage, multiple births, history of delivery of immature, deformed and huge children; viral infections with teratogenic factors within 3 months of pregnancy, such as cytomegalovirus, rubella, etc.; bleeding in early pregnancy; X-ray exposure; smoking habits; endocrine diseases such as diabetes; obesity; Rh and ABO blood group incompatibility. Severe gestational toxicity; infectious diseases in pregnancy, such as toxoplasma gondii, syphilis, tuberculosis, chronic urinary tract infection and herpes simplex; serious diseases in pregnancy, such as heart disease, mental illness, kidney disease, etc.; long-term medication, major surgery, anemia; more than 4 repeated pregnancies; repeated vaginal bleeding, etc. (2) Labor and delivery factors (intrapartum factors): long antecedent labor of more than 24 hours for first birth, more than 12 hours for transitional labor, more than 2 hours for second labor; early water breakage 24 hours before delivery; placenta praevia; placenta abruptio; abnormal turbidity and excess amniotic fluid; abnormal prolapse of the umbilical cord, cervical cord; intrauterine hypoxia; twin and multiple fetuses; breech and face position; high and intermediate forceps; placental dysfunction, severe asphyxia, cesarean section etc. 3. Neonatal factors Birth weight below 2.5 kg and above 4.1 kg, especially very small unripe infants below 2.0 kg; preterm birth within 34 weeks and overdue birth above 43 weeks (unripe infants above 3 weeks and overripe infants above 2 weeks); gestational age and birth weight not corresponding; Apgar score below 4 after 1 minute of asphyxia; sucking weakness or no sucking; neonatal spasms; 2 weeks or more jaundice, exchange transfusion; respiratory disturbances and cyanotic episodes; malformations; birth injuries, hemorrhage; anemia; infections (otitis media, tracheitis, pneumonia, meningitis, etc.); early vomiting, hypoglycemia; central nervous abnormalities; omental disease in immature infants; acidosis; anamnesis; irritability, severe malnutrition in the first postnatal week; delayed weight recovery at birth, etc. Generally speaking, the more and heavier the above factors are, the more likely brain injury will occur, but children without the above factors may also have genetic, malformation and metabolic disorders, which can also cause the disease and should not be ignored.