Ultrasound-guided breast histologic biopsy refers to ultrasound image-guided histopathologic examination of the breast (referred to as biopsy), which is particularly suitable for undetected breast lesions (e.g., small masses, calcified foci, and structural distortions). These include image-guided hollow-core needle aspiration biopsy (CNB), vacuum-assisted biopsy (VAB), and wire-positioned surgical biopsy. Indications for breast ultrasound image guided breast biopsy: (1) suspicious suspicious occupying breast lesions not detected by breast ultrasound, BI-RADS ≥ 4 or some 3 lesions, if necessary, can also be considered for biopsy. (2) A breast lump can be visualized and ultrasound suggests an intramammary occupying lesion in the appropriate area, requiring a minimally invasive biopsy or minimally invasive excision for a definitive diagnosis. The role of breast biopsy: Biopsy can clarify the diagnosis of breast disease and provide a basis for the next step of treatment.