Chemotherapy for gastric cancer does not necessarily make ascites disappear, and it is recommended to combine with ascites drainage, diuretics and albumin supplementation when necessary. Gastric cancer accompanied by ascites often suggests advanced stage of cancer, which can be alleviated by intraperitoneal instillation of cytotoxic drugs to kill cancer cells promoting ascites production and blocking lymphatic vessels. However, the effect of different chemotherapeutic drugs in relieving ascites varies. Among them, fluorouracil and cisplatin are commonly used in the treatment of malignant ascites in gastric cancer, with an effective rate of about 50%. Since chemotherapy does not necessarily make gastric cancer ascites disappear, if gastric cancer is accompanied with large amount of ascites, sexual massive peritoneal puncture and drainage can be considered for control, which can alleviate the accumulation of fluid in the abdominal cavity for a short period of time; clinically, diuretic medicines can also be used to control ascites, such as spironolactone, furosemide, etc. In addition, colloid osmolality can also be improved by replenishing albumin to alleviate the ascites.