Low estradiol during ovulation induction may be a normal phenomenon, or it may be related to pituitary amenorrhea and ovarian failure, which can be treated with medication. 1. Normal phenomenon: Ovulation promotion is usually on the fifth day of menstruation, and estradiol will decrease in the pre-menstrual period as well as during menstruation, and will return to normal after menstruation, which is a normal phenomenon and does not require any special treatment, but if it produces undesirable symptoms, it should be consulted in time. 2. Pituitary amenorrhea: Low estradiol during ovulation may be related to pituitary amenorrhea. Pituitary amenorrhea may cause organic pathology or dysfunction of the pituitary gland, affecting the secretion of gonadotropins, which in turn reduces the level of estradiol. Bromocriptine mesylate tablets, clomiphene citrate tablets, thyroid tablets, etc. can be used according to medical advice. 3. Ovarian dysfunction: low estradiol during ovulation may be related to ovarian dysfunction. Ovarian dysfunction will lead to low estrogen secretion, you can use Kuntai capsule, coenzyme Q10 tablets, folic acid tablets and so on according to the doctor’s instructions. Low estradiol during ovulation should be timely medical treatment, go to the regular hospital examination, the use of specific drugs need to be under the guidance of the doctor, do not self-medication, so as not to cause more serious consequences.