Hepatitis B 125 positivity means that the hepatitis B e antigen, hepatitis B surface antibody and hepatitis B core antibody among the five items of hepatitis B are positive. In this case, it means that the patient is infected with hepatitis B virus, and most of the surface antibodies are low in quantitative value, which may be the protective antibodies produced by the surface antibodies against some subtypes of the virus, but due to the low quantitative value of the antibodies, they do not have a comprehensive effect on the hepatitis B virus, and therefore are not of great clinical significance. Positive surface antigen and core antibodies are still needed, and this group of patients is still infected with the hepatitis B virus. It is also necessary to combine with other indicators, such as liver function and viral quantification, and ultrasound of the liver and biliary system, to assess whether and how the hepatitis B condition needs special treatment. When the result of Hepatitis B 125 is positive, it actually indicates that the patient has been infected with the Hepatitis B virus, and the above test result belongs to the status after infection with the virus. Generally speaking, if the first test result is positive, it indicates that the surface antigen of hepatitis B is positive, and it also indicates that the hepatitis B virus has already replicated and multiplied in the patient’s body. Of course, since the actual situation of each person is different, it is necessary to go to the hospital for further examination to understand the liver function and the morphology and structure of the liver to decide whether it is necessary to treat the symptoms.