Intractable insomnia refers to persistent insomnia, which belongs to the category of “insomnia” in traditional Chinese medicine, and the proprietary Chinese medicines for treating intractable insomnia include Gui Spleen Pill, Sour Jujube Kernel Syrup, and Zhu Sha An Shen Pill. Huisheng Pill: It can be used for persistent insomnia with deficiency of the heart and spleen, with Chinese herbal ingredients including Radix Codonopsis pilosulae, Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Glycyrrhizae Praeparatae, Poria, Radix Polygalae, Radix Jujubae Jubaeaeaeae Sulphate, and so on. It can be used for treating or improving the deficiency of the heart and spleen, shortness of breath, palpitations, insomnia, dizziness, fatigue, and loss of appetite. It should be noted that this product should not be taken by patients with cold and fever, those who have thirst, yellow urine, constipation and other manifestations of internal heat, and there are case reports of this product causing digestive discomfort and skin rashes. Sour Jujube Seed Syrup: It can be used for persistent insomnia that belongs to heart and gallbladder qi deficiency. The herbal ingredients include sour jujube seed, Zhi Mu, Poria, Chuanxiong, and Glycyrrhiza glabra, which have the effect of clearing away heat and diarrhea, nourishing the blood and tranquilizing the mind, and can improve or treat insomnia with deficiency vexation (vexation caused by deficiency heat in the body), palpitations and restlessness, and dizziness. In addition, this product is contraindicated in patients with external fever, pregnant women and diabetic patients should be cautious. Zhu Sha An Shen Pill: The Chinese herbal ingredients include Zhu Sha, Rhizoma Coptidis, Radix Rehmanniae Praeparata, Radix Angelicae Sinensis, Radix et Rhizoma Glycyrrhizae Praeparatae, the efficacy of which is to purify the heart and nourish the blood, and to calm and tranquilize the mind. It can be used to treat or improve the symptoms of chest tightness, palpitations and insomnia. The adverse effects and contraindications of this drug are not clear. There are more proprietary Chinese medicines for the treatment of persistent insomnia, it is recommended to choose the appropriate proprietary Chinese medicine under the guidance of the doctor or pharmacist’s diagnosis and should not be blindly used without authorization to prevent the aggravation of the condition.